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human pca cell lines  (ATCC)


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    ATCC human pca cell lines
    Human Pca Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 2905 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/22rv1+pca+cell+line/22Rv1/pm42229817-37-0-19
    Average 99 stars, based on 2905 article reviews
    human pca cell lines - by Bioz Stars, 2026-10
    99/100 stars

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    Related Articles

    Control:

    Article Title: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    Article Snippet: The following antibodies were used: anti-Sam68 (sc333, Santa Cruz Biotechnology), anti-AR (G122-434) (BDB554225, BD Biosciences), anti-AR (N-20) (sc-816, Santa Cruz Biotechnology), anti-AR-V7 (AG10008, Precision Antibody), anti-SC35 (S4045, Sigma), anti-α-tubulin (TU-02, Santa Cruz Biotechnology), normal mouse IgG (sc-2025, Santa Cruz Biotechnology), anti-mouse IgG HRP-linked (7076, Cell Signaling), anti-rabbit IgG HRP-linked (7074, Cell Signaling), Alexa Fluor® 488 anti-Mouse IgG (A-21203, Life Technologies) and Alexa Fluor® 555 anti-Rabbit IgG (A-21429, Life Technologies). .. The following plasmids have been described previously or are commercially-available: pEGFP3-Sam68 ; pEGFP-Sam68 V229F ; pcDNA3-HA-hnRNPA2-cDNA ; pcDNA3-AR, UASTKLuc, and pCMV-β-Gal ; AR-V7 minigenes ; pLKO-si-Sam68 ; and control pLKO-puro Non-Target shRNA Control (SHC016, Sigma) and pRL-null (E2271, Promega). pM-Sam68 was generated by cloning of the Sam68 coding sequence from pGBTK7-Sam68 into the empty pM vector between Eco RI and Sal I. cFlag AR-V7 was generated by cloning of a PCR-amplified cDNA fragment containing the AR-V7 coding sequence from the 22Rv1 PCa cell line (CRL-2505, ATCC) into c-Flag pcDNA3 between Xho I and Bam HI. p(ARE) 3 Luc contains 3x repeats of the 1st androgen response element (ARE) plus TATA box from KLK3 promoter region cloned into pGL3basic (E1751, Promega). ..

    shRNA:

    Article Title: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    Article Snippet: The following antibodies were used: anti-Sam68 (sc333, Santa Cruz Biotechnology), anti-AR (G122-434) (BDB554225, BD Biosciences), anti-AR (N-20) (sc-816, Santa Cruz Biotechnology), anti-AR-V7 (AG10008, Precision Antibody), anti-SC35 (S4045, Sigma), anti-α-tubulin (TU-02, Santa Cruz Biotechnology), normal mouse IgG (sc-2025, Santa Cruz Biotechnology), anti-mouse IgG HRP-linked (7076, Cell Signaling), anti-rabbit IgG HRP-linked (7074, Cell Signaling), Alexa Fluor® 488 anti-Mouse IgG (A-21203, Life Technologies) and Alexa Fluor® 555 anti-Rabbit IgG (A-21429, Life Technologies). .. The following plasmids have been described previously or are commercially-available: pEGFP3-Sam68 ; pEGFP-Sam68 V229F ; pcDNA3-HA-hnRNPA2-cDNA ; pcDNA3-AR, UASTKLuc, and pCMV-β-Gal ; AR-V7 minigenes ; pLKO-si-Sam68 ; and control pLKO-puro Non-Target shRNA Control (SHC016, Sigma) and pRL-null (E2271, Promega). pM-Sam68 was generated by cloning of the Sam68 coding sequence from pGBTK7-Sam68 into the empty pM vector between Eco RI and Sal I. cFlag AR-V7 was generated by cloning of a PCR-amplified cDNA fragment containing the AR-V7 coding sequence from the 22Rv1 PCa cell line (CRL-2505, ATCC) into c-Flag pcDNA3 between Xho I and Bam HI. p(ARE) 3 Luc contains 3x repeats of the 1st androgen response element (ARE) plus TATA box from KLK3 promoter region cloned into pGL3basic (E1751, Promega). ..

    Generated:

    Article Title: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    Article Snippet: The following antibodies were used: anti-Sam68 (sc333, Santa Cruz Biotechnology), anti-AR (G122-434) (BDB554225, BD Biosciences), anti-AR (N-20) (sc-816, Santa Cruz Biotechnology), anti-AR-V7 (AG10008, Precision Antibody), anti-SC35 (S4045, Sigma), anti-α-tubulin (TU-02, Santa Cruz Biotechnology), normal mouse IgG (sc-2025, Santa Cruz Biotechnology), anti-mouse IgG HRP-linked (7076, Cell Signaling), anti-rabbit IgG HRP-linked (7074, Cell Signaling), Alexa Fluor® 488 anti-Mouse IgG (A-21203, Life Technologies) and Alexa Fluor® 555 anti-Rabbit IgG (A-21429, Life Technologies). .. The following plasmids have been described previously or are commercially-available: pEGFP3-Sam68 ; pEGFP-Sam68 V229F ; pcDNA3-HA-hnRNPA2-cDNA ; pcDNA3-AR, UASTKLuc, and pCMV-β-Gal ; AR-V7 minigenes ; pLKO-si-Sam68 ; and control pLKO-puro Non-Target shRNA Control (SHC016, Sigma) and pRL-null (E2271, Promega). pM-Sam68 was generated by cloning of the Sam68 coding sequence from pGBTK7-Sam68 into the empty pM vector between Eco RI and Sal I. cFlag AR-V7 was generated by cloning of a PCR-amplified cDNA fragment containing the AR-V7 coding sequence from the 22Rv1 PCa cell line (CRL-2505, ATCC) into c-Flag pcDNA3 between Xho I and Bam HI. p(ARE) 3 Luc contains 3x repeats of the 1st androgen response element (ARE) plus TATA box from KLK3 promoter region cloned into pGL3basic (E1751, Promega). ..

    Cloning:

    Article Title: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    Article Snippet: The following antibodies were used: anti-Sam68 (sc333, Santa Cruz Biotechnology), anti-AR (G122-434) (BDB554225, BD Biosciences), anti-AR (N-20) (sc-816, Santa Cruz Biotechnology), anti-AR-V7 (AG10008, Precision Antibody), anti-SC35 (S4045, Sigma), anti-α-tubulin (TU-02, Santa Cruz Biotechnology), normal mouse IgG (sc-2025, Santa Cruz Biotechnology), anti-mouse IgG HRP-linked (7076, Cell Signaling), anti-rabbit IgG HRP-linked (7074, Cell Signaling), Alexa Fluor® 488 anti-Mouse IgG (A-21203, Life Technologies) and Alexa Fluor® 555 anti-Rabbit IgG (A-21429, Life Technologies). .. The following plasmids have been described previously or are commercially-available: pEGFP3-Sam68 ; pEGFP-Sam68 V229F ; pcDNA3-HA-hnRNPA2-cDNA ; pcDNA3-AR, UASTKLuc, and pCMV-β-Gal ; AR-V7 minigenes ; pLKO-si-Sam68 ; and control pLKO-puro Non-Target shRNA Control (SHC016, Sigma) and pRL-null (E2271, Promega). pM-Sam68 was generated by cloning of the Sam68 coding sequence from pGBTK7-Sam68 into the empty pM vector between Eco RI and Sal I. cFlag AR-V7 was generated by cloning of a PCR-amplified cDNA fragment containing the AR-V7 coding sequence from the 22Rv1 PCa cell line (CRL-2505, ATCC) into c-Flag pcDNA3 between Xho I and Bam HI. p(ARE) 3 Luc contains 3x repeats of the 1st androgen response element (ARE) plus TATA box from KLK3 promoter region cloned into pGL3basic (E1751, Promega). ..

    Sequencing:

    Article Title: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    Article Snippet: The following antibodies were used: anti-Sam68 (sc333, Santa Cruz Biotechnology), anti-AR (G122-434) (BDB554225, BD Biosciences), anti-AR (N-20) (sc-816, Santa Cruz Biotechnology), anti-AR-V7 (AG10008, Precision Antibody), anti-SC35 (S4045, Sigma), anti-α-tubulin (TU-02, Santa Cruz Biotechnology), normal mouse IgG (sc-2025, Santa Cruz Biotechnology), anti-mouse IgG HRP-linked (7076, Cell Signaling), anti-rabbit IgG HRP-linked (7074, Cell Signaling), Alexa Fluor® 488 anti-Mouse IgG (A-21203, Life Technologies) and Alexa Fluor® 555 anti-Rabbit IgG (A-21429, Life Technologies). .. The following plasmids have been described previously or are commercially-available: pEGFP3-Sam68 ; pEGFP-Sam68 V229F ; pcDNA3-HA-hnRNPA2-cDNA ; pcDNA3-AR, UASTKLuc, and pCMV-β-Gal ; AR-V7 minigenes ; pLKO-si-Sam68 ; and control pLKO-puro Non-Target shRNA Control (SHC016, Sigma) and pRL-null (E2271, Promega). pM-Sam68 was generated by cloning of the Sam68 coding sequence from pGBTK7-Sam68 into the empty pM vector between Eco RI and Sal I. cFlag AR-V7 was generated by cloning of a PCR-amplified cDNA fragment containing the AR-V7 coding sequence from the 22Rv1 PCa cell line (CRL-2505, ATCC) into c-Flag pcDNA3 between Xho I and Bam HI. p(ARE) 3 Luc contains 3x repeats of the 1st androgen response element (ARE) plus TATA box from KLK3 promoter region cloned into pGL3basic (E1751, Promega). ..

    Polymerase Chain Reaction:

    Article Title: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    Article Snippet: The following antibodies were used: anti-Sam68 (sc333, Santa Cruz Biotechnology), anti-AR (G122-434) (BDB554225, BD Biosciences), anti-AR (N-20) (sc-816, Santa Cruz Biotechnology), anti-AR-V7 (AG10008, Precision Antibody), anti-SC35 (S4045, Sigma), anti-α-tubulin (TU-02, Santa Cruz Biotechnology), normal mouse IgG (sc-2025, Santa Cruz Biotechnology), anti-mouse IgG HRP-linked (7076, Cell Signaling), anti-rabbit IgG HRP-linked (7074, Cell Signaling), Alexa Fluor® 488 anti-Mouse IgG (A-21203, Life Technologies) and Alexa Fluor® 555 anti-Rabbit IgG (A-21429, Life Technologies). .. The following plasmids have been described previously or are commercially-available: pEGFP3-Sam68 ; pEGFP-Sam68 V229F ; pcDNA3-HA-hnRNPA2-cDNA ; pcDNA3-AR, UASTKLuc, and pCMV-β-Gal ; AR-V7 minigenes ; pLKO-si-Sam68 ; and control pLKO-puro Non-Target shRNA Control (SHC016, Sigma) and pRL-null (E2271, Promega). pM-Sam68 was generated by cloning of the Sam68 coding sequence from pGBTK7-Sam68 into the empty pM vector between Eco RI and Sal I. cFlag AR-V7 was generated by cloning of a PCR-amplified cDNA fragment containing the AR-V7 coding sequence from the 22Rv1 PCa cell line (CRL-2505, ATCC) into c-Flag pcDNA3 between Xho I and Bam HI. p(ARE) 3 Luc contains 3x repeats of the 1st androgen response element (ARE) plus TATA box from KLK3 promoter region cloned into pGL3basic (E1751, Promega). ..

    Clone Assay:

    Article Title: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
    Article Snippet: The following antibodies were used: anti-Sam68 (sc333, Santa Cruz Biotechnology), anti-AR (G122-434) (BDB554225, BD Biosciences), anti-AR (N-20) (sc-816, Santa Cruz Biotechnology), anti-AR-V7 (AG10008, Precision Antibody), anti-SC35 (S4045, Sigma), anti-α-tubulin (TU-02, Santa Cruz Biotechnology), normal mouse IgG (sc-2025, Santa Cruz Biotechnology), anti-mouse IgG HRP-linked (7076, Cell Signaling), anti-rabbit IgG HRP-linked (7074, Cell Signaling), Alexa Fluor® 488 anti-Mouse IgG (A-21203, Life Technologies) and Alexa Fluor® 555 anti-Rabbit IgG (A-21429, Life Technologies). .. The following plasmids have been described previously or are commercially-available: pEGFP3-Sam68 ; pEGFP-Sam68 V229F ; pcDNA3-HA-hnRNPA2-cDNA ; pcDNA3-AR, UASTKLuc, and pCMV-β-Gal ; AR-V7 minigenes ; pLKO-si-Sam68 ; and control pLKO-puro Non-Target shRNA Control (SHC016, Sigma) and pRL-null (E2271, Promega). pM-Sam68 was generated by cloning of the Sam68 coding sequence from pGBTK7-Sam68 into the empty pM vector between Eco RI and Sal I. cFlag AR-V7 was generated by cloning of a PCR-amplified cDNA fragment containing the AR-V7 coding sequence from the 22Rv1 PCa cell line (CRL-2505, ATCC) into c-Flag pcDNA3 between Xho I and Bam HI. p(ARE) 3 Luc contains 3x repeats of the 1st androgen response element (ARE) plus TATA box from KLK3 promoter region cloned into pGL3basic (E1751, Promega). ..



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    Image Search Results


    The PDPK1/AKT/FLT DPI and tenovin-6 (T6) show high anti-cancer efficacy in murine tumoroids and human PCa cell lines (A) Dose-response curves for DPI (top) and T6 (bottom) for in vivo and in vitro Pten KO (left), Pten/Stat3 KO (middle), and Pten/Tp53 KO (right) tumoroids. Points represent means of technical duplicates per tumoroid line ( N = 3). Curve fitting was performed using GraphPad Prism 8.0.2. (B) Bar graphs showing means and ±SD of half-maximal inhibitory concentration (IC50) for DPI (top) and T6 (bottom) for in vivo and in vitro tumoroid lines of all genotypes ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA, Tukey’s test). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05. (C) Bar graphs depicting means and ±SD of IC50 values of DPI (left) and T6 (right) on human PCa cell lines. 22RV1: primary PCa; LNCaP: metastatic PCa; DU145, PC3: metastatic castration-resistant PCa ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05; ∗∗ p ≤ 0.01. (D) Heatmaps of synergy scores calculated with the highest single agent (HSA) model for DPI and enzalutamide (left), and T6 and enzalutamide (right) on the human LNCaP cell line. Values > 0 represent synergistic effects, and values < 0 represent antagonistic effects. IC50 concentrations of respective compounds are underlined ( N = 3). See also .

    Journal: Cell Reports Methods

    Article Title: Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss

    doi: 10.1016/j.crmeth.2026.101370

    Figure Lengend Snippet: The PDPK1/AKT/FLT DPI and tenovin-6 (T6) show high anti-cancer efficacy in murine tumoroids and human PCa cell lines (A) Dose-response curves for DPI (top) and T6 (bottom) for in vivo and in vitro Pten KO (left), Pten/Stat3 KO (middle), and Pten/Tp53 KO (right) tumoroids. Points represent means of technical duplicates per tumoroid line ( N = 3). Curve fitting was performed using GraphPad Prism 8.0.2. (B) Bar graphs showing means and ±SD of half-maximal inhibitory concentration (IC50) for DPI (top) and T6 (bottom) for in vivo and in vitro tumoroid lines of all genotypes ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA, Tukey’s test). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05. (C) Bar graphs depicting means and ±SD of IC50 values of DPI (left) and T6 (right) on human PCa cell lines. 22RV1: primary PCa; LNCaP: metastatic PCa; DU145, PC3: metastatic castration-resistant PCa ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05; ∗∗ p ≤ 0.01. (D) Heatmaps of synergy scores calculated with the highest single agent (HSA) model for DPI and enzalutamide (left), and T6 and enzalutamide (right) on the human LNCaP cell line. Values > 0 represent synergistic effects, and values < 0 represent antagonistic effects. IC50 concentrations of respective compounds are underlined ( N = 3). See also .

    Article Snippet: Human 22RV1 primary PCa cell line , ATCC , CRL-2505; RRID:CVCL_1045.

    Techniques: In Vivo, In Vitro, Concentration Assay